Multivitamins/Minerals (with ADEK, Folate, Iron): May decrease the serum concentration of Quinolones. Specifically, polyvalent cations in multivitamin products may decrease the absorption of orally administered quinolone antibiotics. Management: Administer oral quinolones at least 2 hours before, or 6 hours after, the dose of a multivitamin that contains polyvalent cations (ie, calcium, iron, magnesium, selenium, zinc). Monitor for decreased quinolone efficacy. Consider therapy modification
Multivitamins/Minerals (with AE, No Iron): May decrease the serum concentration of Quinolones. Specifically, minerals in the multivitamin/mineral product may impair absorption of quinolone antibiotics. Management: Administer oral quinolones at least 2 hours before, or 6 hours after, the dose of a multivitamin that contains polyvalent cations (ie, calcium, iron, magnesium, selenium, zinc). Monitor for decreased therapeutic effects of quinolones. Consider therapy modification
A novel kind of highly efficient and antibacterial thermal stabilizer, zinc norfloxacin (Zn(C16H17FN3O3)2·4H2O, represented as ZnNo2), for poly(vinyl chloride) (PVC) was first reported in this paper; the structure of which was characterized by Fourier-transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), elemental analysis, scanning electron microscopy (SEM), X-ray diffraction (XRD) and laser particle size analysis.
Three novel complexes of norfloxacin (abbreviated as NFL), [M(NFL)2(H2O2]Cl3·6H2O, (M = Fe, Co), and [Zn(NFL)2]Cl2·7H2O, have been prepared. The compounds were characterized by IR, UV-Vis, NMR spectra, molar conductivity, and elemental analyses. In all of the complexes, the ligand NFL was coordinated through two carboxyl oxygen atoms. Octahedral and tetrahegon geometries have been proposed for Fe(III)-, Co(II)-complexes and Zn(II)-complex, respectively. In vitro test of susceptibility of Fe(III)- and Zn(II)-complexes showed stronger activity than that of norfloxacin against G(−) E. Coli and Bacillus dysenteriae bacteria.
Zinc oxide nanoparticles with antibiotics inhibited hydrolysis, fermentation, and methanogenesis over varying digestion periods. Complex pollution had a greater impact on methane production than zinc oxide alone, with acute, synergistic toxicity to methanogenesis over short periods. Complex pollution also had varying effects on bacterial and archaeal communities during digestion. These results aid understanding of the toxicity of emerging contaminants in sludge digestion, with the potential to improve pollution removal and reduce associated risks.