6日，重庆医科大学发布消息，由该校黄爱龙教授/金艾顺教授团队牵头的研究，发现了对新冠奥密克戎变异株具有强效中和活性的抗体58G6，并证明了滴鼻给药方式阻断奥密克戎变异株复制的有效性。相关论文近日发表于期刊《信号转导与靶向治疗》上。
“新冠病毒每变异一次，全球众多科研机构研发的中和抗体就失效一批，特别是奥密克戎具有更多突变位点，原来有效的中和抗体幸存下来的也不多了。很幸运，我们筛选出的58G6中和抗体仍然保持有效中和活性。”金艾顺介绍，他们和武汉病毒研究所团队共同鉴定出的抗体58G6，单独使用就能对阿尔法、贝塔、伽马、德尔塔、奥密克戎等多种受关注的新冠病毒突变体的假病毒表现出强效中和能力，显示其具有广谱中和活性。
研究人员通过滴鼻给药的方式，检验此抗体在仓鼠体内的中和效力。结果表明，很低浓度（2毫克/公斤）的58G6鼻腔给药，就可以有效预防仓鼠感染奥密克戎活病毒。
黄爱龙介绍，目前由该校主导研发的新冠病毒中和抗体鼻喷药物（预防用）已经完成全部临床前研究资料的准备，近日已提交国家药监局新药评审中心。
参考自《科技日报》2022年09月07日第1版
论文链接，附论文摘要：
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still rapidly spreading worldwide. Many drugs and vaccines have been approved for clinical use show efficacy in the treatment and prevention of SARS-CoV-2 infections. However, the emergence of SARS-CoV-2 variants of concern (VOCs), such as Delta (B.1.617.2) and the recently emerged Omicron (B.1.1.529), has seriously challenged the application of current therapeutics. Therefore, there is still a pressing need for identification of new broad-spectrum antivirals. Here, we further characterized a human antibody (58G6), which we previously isolated from a patient, with a broadly authentic virus-neutralizing activity that inhibits the Delta and Omicron variants with half-maximal inhibitory concentrations (IC50) of 1.69 ng/ml and 54.31 ng/ml, respectively. 58G6 shows prophylactic and therapeutic efficacy in hamsters challenged with the Delta and Omicron variants through nasal delivery. Notably, a very low dosage (2 mg/kg daily) of 58G6 efficiently prevented Omicron variant replication in the lungs. These advantages may overcome the efficacy limitation of currently approved neutralizing antibodies that can be administered only by intravenous injection. In general, 58G6 is a promising prophylactic and therapeutic candidate against current circulating VOCs and even future emerging mutants. To the best of our knowledge, 58G6 is one of the most potent neutralizing antibodies against Omicron, with a broader spectrum than those approved for clinical use. 58G6 could be developed as a nebulized therapy, which would be more cost effective and user friendly and enhance the clinical outcome compared to that obtained with direct nasal delivery.